Isotope Effects; Oxygen metabolism (oxidases); Nitrogen metabolism (nitrogenase, glutamine synthetase).
Biophysical chemistry of proteins
Electrostatics, folding, quaternary structure.
Drug design for orphan diseases; Biomarker for amyotrophic lateral sclerosis (ALS); Neurochemistry.
Geochemistry and Biogeochemistry.
Biomineralization and extreme environments.
Example presentation on enzymology of extreme microorganisms: "Thermotoga flavin-dependent thymidylate synthase: Implications for oxygen metabolism",Thermotoga 2007 Workshop
For the list of publications see the CV.